Musculo-skeletal adaptations to exercise, disuse, disease and ageing

The main focus of this research area is the study how the structure and function of human muscles, tendons and joints are all altered in response to:

  • acute exercise and exercise training
  • chronic disuse (for example immobilization following a spinal cord injury, during a space flight or enforced confinement)
  • ageing

Muscles, tendons and joints are being studied in vivo, using non-invasive scanning techniques such as ultrasonography and magnetic resonance imaging (MRI) to establish structural adaptation and their functional consequences.

These studies enhance our knowledge on the biomechanical factors involved in the transmission of contractile forces to the skeleton to produce movement and provide crucial information as to how we can best intervene to ameliorate deteriorations in musculoskeletal structure and function, and improve daily mobility and athletic performance.

Ultrasound scanners dedicated for in vivo muscle and tendon research are available at the RISES and links with other institutes exist for accessing MRI and fluoroscopy scanning facilities and the study of joint structure and function.

Our staff

  • Prof Costis Maganaris
  • Prof Tom O’Brien
  • Prof Bill Baltzopoulos
  • Dr  Theo Bampouras

Primary contact

  • Prof Costis Maganaris

Publication spotlights

Comparative analysis of muscle synergies in gait of stroke patients and healthy controls

Supersonic shear wave elastography of human tendons is associated with in vivo tendon stiffness over small strains

Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age

Automated Method for Tracking Human Muscle Architecture on Ultrasound Scans during Dynamic Tasks

Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males

Impact of sedentarism due to the COVID-19 home confinement on neuromuscular, cardiovascular and metabolic health: Physiological and pathophysiological implications and recommendations for physical and nutritional countermeasures

Ankle Motion Is Associated With Soft Tissue Displacement in the Dorsal Thigh: An in vivo Investigation Suggesting Myofascial Force Transmission Across the Knee Joint

Gastrocnemius Medialis and Vastus Lateralis in vivo muscle-tendon behavior during running at increasing speeds

Fascial tissue research in sports medicine: from molecules to tissue adaptation, injury and diagnostics: consensus statement

The role of muscle strength on tendon adaptability in old age

Muscle and Tendon Contributions to Reduced Rate of Torque Development in Healthy Older Males

Altered Achilles tendon function during walking in people with diabetic neuropathy: implications for metabolic energy saving

Quantification of Internal Stress-Strain Fields in Human Tendon: Unraveling the Mechanisms that Underlie Regional Tendon Adaptations and Mal-Adaptations to Mechanical Loading and the Effectiveness of Therapeutic Eccentric Exercise

The Achilles tendon is mechanosensitive in older adults: adaptations following 14 weeks versus 1.5 years of cyclic strain exercise

Altered leverage around the ankle in people with diabetes: A natural strategy to modify the muscular contribution during walking?

Interplay between body stabilisation and quadriceps muscle activation capacity

The role of agonist and antagonist muscles in explaining isometric knee extension torque variation with hip joint angle

Obstetrics and Gynecology Trainees Face Higher Musculoskeletal Demands than General Surgery Trainees in Simulated Laparoscopic Tasks—An Observational Study

Effect of Intra-Set Rest Periods on Back Squat Propulsive Impulse

Acute Effects of Intracontrast Rest After Back Squats on Vertical Jump Performance During Complex Training

Surgical Stress: The Muscle and Cognitive Demands of Robotic and Laparoscopic Surgery

Should All Minimal Access Surgery Be Robot-Assisted? A Systematic Review into the Musculoskeletal and Cognitive Demands of Laparoscopic and Robot-Assisted Laparoscopic Surgery

Weighted vests in CrossFit increase physiological stress during walking and running without changes in spatiotemporal gait parameters

High Intensity Interval Training (HIIT) as a Potential Countermeasure for Phenotypic Characteristics of Sarcopenia: A Scoping Review

Effect of environmental temperature change on the neuromechanical function of the quadriceps muscle

Mechanisms of head stability during gait initiation in young and older women: A neuro-mechanical analysis

Head flexion and different walking speeds do not affect gait stability in older females

Carrying shopping bags does not alter static postural stability and gait parameters in healthy older females

Homogeneity of fascicle architecture following repeated contractions in the human gastrocnemius medialis

Postural stability of older female Scottish country dancers in comparison with physically active controls